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1. Authorized operator – Curacao jurisdiction;
2. Date of creation – year 2023;
3. Freebie offers: membership program, cashback, extra spins, starter packages;
4. Gaming options: slot machines, keno, scratch cards, baccarat, poker, live-games;
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Licensed business	Malta (MGA)
Inception date	year 2011
Types of casino games	slots, bingo, blackjack, poker, live dealer games
Player rewards	initial bonuses, membership program, no-cost spins, cashback
Online payment options	charge cards (Visa, Mastercard, Maestro), e-wallets (PayPal, Neteller, Skrill, ecoPayz), local payment systems (Interac, iDEAL, Qiwi), bank transfers (SWIFT, SEPA) and crypto tokens (Litecoin, Tether, Bitcoin, Ethereum)

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Year of Establishment	year 2022
Permit obtained from	Curacao Gaming Authority
Game Creators	iSoftBet, Thunderkick, Big Time Gaming, IGT, Rabcat, Betsoft and more
Minimum funding amount	A$50
Technical help service	help center email, instant chat, online inquiry form, client assistance phone

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• Peliosis hepatis, una condición en la cual el hígado y, a veces, el tejido esplénico se reemplaza con quistes llenos de sangre, se ha informado en pacientes que reciben terapia con esteroides anabólicos androgénicos.
• La administración concomitante con esteroides suprarrenales o ACTH puede aumentar el edema.

En ratas macho, no se clasificaron efectos como neoplásicos en respuesta a dosis de hasta one hundred fifty mg/kg/día (5 veces exposiciones terapéuticas con 5 mg/kg basadas en la superficie corporal). Se ha observado leucemia en pacientes con anemia aplásica tratados con oximetolona. El papel, en su caso, de la oximetolona no está claro porque se ha observado una transformación maligna en pacientes con discrasias sanguíneas y se ha notificado leucemia en pacientes con anemia aplásica que no han sido tratados con oximetolona. El edema con o sin insuficiencia cardíaca congestiva puede ser una complicación grave en pacientes con enfermedad cardíaca, renal o hepática preexistente. La administración concomitante con esteroides suprarrenales o ACTH puede aumentar el edema. Esto generalmente se puede controlar con una terapia diurética y / o digital adecuada.

Anapolon

Algunos cambios virilizantes en las mujeres son irreversibles incluso después de la interrupción inmediata de la terapia y no se previenen mediante el uso concomitante de estrógenos. La hepatitis colestásica y la ictericia ocurren con andrógenos 17-alfa-alquilados a dosis relativamente bajas. También puede estar asociado con agrandamiento hepático agudo y dolor del cuadrante superior derecho, que se ha confundido con obstrucción aguda (quirúrgica) del conducto biliar. La ictericia inducida por medicamentos suele ser reversible cuando se suspende el medicamento.

Una dosis de mantenimiento continuada es generalmente necesaria en pacientes con anemia aplásica congénita. Los pacientes varones geriátricos tratados con esteroides anabólicos androgénicos pueden tener un mayor riesgo de desarrollar hipertrofia prostática y carcinoma prostático. Se realizó un estudio de carcinogenicidad de dos años de duración en ratas que recibieron oximetolona por vía oral bajo los auspicios del Programa Nacional de Toxicología de los EE.).

Otras experiencias clínicas notificadas no han identificado diferencias en las respuestas entre los pacientes de edad avanzada y los pacientes más jóvenes. Las mujeres deben ser observadas para detectar signos de virilización (profundización de la voz, hirsutismo, acné y clitoromegalia). Para prevenir un cambio irreversible, la terapia con medicamentos debe suspenderse cuando se detecta por primera vez un virilismo leve. Tal virilización es traditional después del uso de esteroides anabólicos androgénicos en dosis altas.

Si se detecta deficiencia de hierro, debe tratarse adecuadamente con hierro suplementario. La hemoglobina y el hematocrito deben revisarse periódicamente para detectar policitemia en pacientes que están recibiendo altas dosis de anabólicos. La insulina o la dosis hipoglucemiante oral pueden necesitar ajustes en pacientes diabéticos que reciben esteroides anabólicos.

Anapolon Tablets está indicado en el tratamiento de las anemias causadas por la producción deficiente de glóbulos rojos. La anemia aplásica adquirida, la anemia aplásica congénita, la mielofibrosis y las anemias hipoplásicas debidas a la administración de medicamentos mielotóxicos a menudo responden. Sin embargo, como se indica a continuación en REACCIONES ADVERSAS, oligospermia en varones y amenorrhea en mujeres son efectos adversos potenciales del tratamiento con Anapolon tabletas. Por lo tanto, el deterioro de la fertilidad es un posible resultado del tratamiento con Anapolon Tablets. Debido a que se ha observado anemia por deficiencia de hierro en algunos pacientes tratados con oximetolona, se recomienda la determinación periódica del hierro sérico y la capacidad de unión al hierro.

Los cambios en los lípidos en la sangre que se sabe que están asociados con un mayor riesgo de aterosclerosis se observan en pacientes tratados con andrógenos y esteroides anabólicos. Estos cambios incluyen la disminución de la lipoproteína de alta densidad y, a veces, el aumento de la lipoproteína de baja densidad. Los cambios pueden ser muy marcados y podrían tener un grave impacto en el riesgo de aterosclerosis y enfermedad arterial coronaria.

Los esteroides anabólicos / androgénicos deben usarse con mucha precaución en niños y solo por especialistas que conozcan sus efectos sobre la maduración ósea. Debido a la hepatoxicidad asociada con el uso de andrógenos 17-alfa-alquilados, las pruebas de función hepática deben obtenerse periódicamente. En pacientes con cáncer de mama, la terapia con esteroides anabólicos puede causar hipercalcemia al estimular la osteólisis.

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